Bioactive Nutrition 2022-09-20 11:17 Published in Shandong
“About half of Chinese people have Helicobacter pylori in their stomachs, but they don't know it”, said Barry Marshall, an Australian gastroenterologist and winner of the 2005 Nobel Prize in Physiology and Medicine, in an exclusive interview. More than 85% of gastric cancer in the world is attributed to Helicobacter pylori infection, which is also the main cause of chronic gastritis, and can also lead to a series of gastrointestinal diseases of varying degrees such as indigestion and peptic ulcer.
China is an area with a high incidence of Helicobacter pylori infection. As people pay more attention to health, more and more people will actively participate in the treatment after detection of Helicobacter pylori infection. Facing the dilemma of increasing antibiotic resistance and gastrointestinal adverse reactions associated with antibiotic treatment, seeking alternative prevention methods to the infection has become a hot spot of global concern.
How do I know if I have Helicobacter pylori infection?
Generally speaking, there are no particularly obvious manifestations in the initial stage of infection with Helicobacter pylori (Hp). But if the following symptoms occur, everyone should be careful whether they have been infected with Hp.
1. Epigastric discomfort, stomach fullness, dull pain, acid regurgitation or belching.
2. bad breath. After infection with Helicobacter pylori, the foul smell caused by the secretions produced by the bacteria will be emitted through the mouth.
3. weight loss or anemia. Impaired nutrient intake by the body due to indigestion.
There are two methods of Hp infection diagnosis.
1. Gastroscopy. Colonization of Hp is detected by obtaining some gastric mucosal tissue；
2. C13/C14 Urea breath test or blood antibody test.
Although Hp is not highly contagious, family aggregation is common, so family-based protection strategy is essential. Family transmission of Hp is often through diet, which can be prevented by the following measures:
1 Keep food hygienic and disinfect utensils.
2 Promote individual serving meals and avoid serving foods from the same dish; Use serving utensils and avoid sharing personal utensils.
3 Pay attention to personal hygiene and wash hands before meals
What to do if infected with Helicobacter pylori?
For people who have been infected with Hp, doctors often recommend active eradication. It is recommended for Hp infected patients to take a 14-day course of bismuth quadruple therapy as the initial and retreatment plan, according to "The Sixth National Guidelines for the Treatment of Helicobacter Pylori Infection 2022”.
| Program | Acid-suppressing drug PPI | Bismuth | antibiotic 1 | antibiotic 2 |
| 1 | √ | √ | Amoxicillin | clarithromycin |
| 2 | √ | √ | Amoxicillin | Levofloxacin |
| 3 | √ | √ | tetracycline | Metronidazole |
| 4 | √ | √ | Amoxicillin | Metronidazole |
| 5 | √ | √ | Amoxicillin | tetracycline |
From "The Sixth National Guidelines for the Treatment of Helicobacter Pylori Infection 2022”
Today, clinical quadruple therapy eradication of Hp is facing severe challenges. Studies have found that the resistance of Helicobacter pylori to antibiotics has increased significantly in most parts of the world, and clinical studies have found that the eradication rate of quadruple therapy is declining simultaneously. On the other hand, the gastrointestinal adverse reactions caused by antibiotic therapy also lead to the resistance of infected patients to clinical treatment.
Therefore, finding alternative anti-Helicobacter pylori solutions has become an intriguing topic in the development of functional foods, and many studies have found that probiotics and bioactive polysaccharides can play a role in eliminating Hp infection.
Mild adjuvant anti-Helicobacter pylori regimen AbateHPTM
AbateHPTM is an anti-Helicobacter pylori program jointly developed by Bloomage Biotech Inc. and the Probiotics Joint Innovation Research Center of Jiangnan University. Through in vitro screening, animal screening and function studies, the combination of the specific probiotic Lactobacillus rhamnosus CCFM1259 and the patented anti-Helicobacter pylori bioactive polysaccharide sodium hyaluronate formulation was selected and the beneficial ingredients of prebiotics were added to finalize the anti-Helicobacter pylori solution — AbateHPTM.
People diagnosed with Helicobacter pylori infected
It is recommended to use AbateHPTM for one month after bismuth quadruple therapy, which can improve the eradication rate of Hp and alleviate gastrointestinal adverse reactions.
People diagnosed with weak Hp positive
It is recommended to use AbateHPTM alone for a course of more than 8 weeks, which can effectively remove Hp and improve gastrointestinal function.
- Advantage of AbateHPTM
1 Efficacy composition of selected specific probiotics + patented bioactive polysaccharide (HA) + prebiotics
2 Scientific clinical verification of anti-Helicobacter pylori effect is remarkable.
3 Oral trial in a mass population testing confirms significant improvement in gastrointestinal symptoms.
- Mechanism of AbateHPTM
1 The specific probiotic Lactobacillus rhamnosus CCFM1259 can significantly inhibit the growth of Hp, thereby reducing the proliferation of Hp.
2 Lactobacillus rhamnosus CCFM1259 can resist the adhesion of Hp to gastric epithelial cells, thereby reducing the colonization of Hp in gastric mucosa.
3 The patented anti-Helicobacter pylori active polysaccharide HA can compete with Hp virulence protein for CD44 binding sites, thereby alleviating the inflammatory response
In the gastric environment, the AbateHPTM composition can accurately identify Hp, promote the excretion of Hp from the stomach by reducing the proliferation of Hp and colonization in the gastric mucosa, and at the same time relieve the inflammatory response caused by Hp and mitigate gastrointestinal discomfort.