Bloomage Biotech Bioactive 15:31 October 31, 2022, Published in Shandong
Ectoine, identified in halophilic bacteria that survive in extreme environments, serves as an osmoprotectant and thus helps organisms survive extreme osmotic stress. In addition, Ectoine can relieve inflammation by forming a hydration shell outside the cells thus reducing the effect of allergens and other substances on the cells and alleviating the development of inflammation.
During the inflammation period, allergens, pollutants and environmental damage pose an impact on the normal life activity of cells, and allergens will invade the cells, resulting in the failure of normal life activities of cells. The external polar end of the Ectoine hydrated phospholipid molecule enhances membrane fluidity, confers resistance towards allergens and other damage, and maintains normal cellular life activities.
Ectoine's resistance to inflammation can be applied to nasal care products. Currently, over 300 million people are suffering from rhinitis in China. It gives a huge market potential for nasal care solutions which can relieve the symptoms of rhinitis. The core products available on the market are isotonic or hypertonic products based on sea salt. Compounding Ectoine in such products can clean the nasal cavity, protect the nasal cells, reduce the impact of a hypertonic environment, and alleviate inflammation.
At the same time, Ectoine can protect epithelial cells of the nasal mucosa in dry environment. In the experiment, the proliferation rate of nasal mucosal epithelial cells decreased by 22.74% after drying, however, addition of Ectoine at different concentrations all increased cell proliferation rate significantly. In the other test group, the damaged cells showed an increase in cell migration rate and a significant decrease in cell damage area after 24 hours of incubation with the addition of Ectoine, demonstrating that Ectoine can protect cells and repair damage.
As a natural substance, Ectoine has good safety, compatibility, and tolerance. Ectoine has stable chemical properties, where operations such as sterilization and pH adjustment during the production of terminal products pose no impact on its stability. Based on its own fermentation R & D platform, Bloomage Biotech has developed a high-quality Bloomecto™ Ectoine raw material with high purity and stability that can be used in nasal spray medical devices. Meanwhile, based on its in-depth technical research, Bloomage Biotech is capable of providing support in formulation and efficacy to medical device manufacturers to accelerate the development and marketing of terminal products.
As a well-known biotechnology and biomaterial company, Bloomage Biotech (688363. SH) will adhere to the “long-term” development concept to strengthen core competitiveness and truly immunize the company, relying on science and technology, building product strength, and shaping brand power. Make national products that let the Chinese feel confident and proud, and become a national enterprise respected and loved by the world.